产品货号：
GS4905
中文名称：
重组人Bcl-2
英文名称：
Recombinant Human B-cell Lymphoma 2
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 23.2kDa,a single non-glycosylated polypeptide chain containing 210 amino acids.
储存条件：冷冻（-20℃）
概述
B-cell lymphoma 2(Bcl-2)is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human.Bcl-2
forms homodimer and heterodimers with other Bcl-2 family proteins,like BAX,BAK,BAD and Bcl-xL.Alternative splicing of
Bcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity.Bcl-2 suppresses apoptosis by
controlling the mitochondrial membrane permeability.It inhibits caspase activity either by preventing the release of cytochrome c
from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1).Antibodies to Bcl-2 can be used with
immunohistochemistry to identify cells containing the antigen.In some cases,the presence or absence of Bcl-2 staining in
biopsies may be significant for the patients prognosis or likelihood of cancer relapse.Mature human Bcl-2 shares 88%- 90%
amino acid sequence identity with murine,rat,bovine,canine Bcl-2.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further
evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人Bcl-2，Bcl-2, Human，Recombinant Human B-cell Lymphoma 2
储存条件：冷冻（-20℃）
概述
B-cell lymphoma 2(Bcl-2)is the founding member of the Bcl-2 family and it is encoded by the BCL2 gene in human.Bcl-2
forms homodimer and heterodimers with other Bcl-2 family proteins,like BAX,BAK,BAD and Bcl-xL.Alternative splicing of
Bcl-2 results in two isoforms with similar folds despite differences in anti-apoptotic activity.Bcl-2 suppresses apoptosis by
controlling the mitochondrial membrane permeability.It inhibits caspase activity either by preventing the release of cytochrome c
from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1).Antibodies to Bcl-2 can be used with
immunohistochemistry to identify cells containing the antigen.In some cases,the presence or absence of Bcl-2 staining in
biopsies may be significant for the patients prognosis or likelihood of cancer relapse.Mature human Bcl-2 shares 88%- 90%
amino acid sequence identity with murine,rat,bovine,canine Bcl-2.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further
evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile liquid. |
| Purity: | ＞95%by SDS-PAGE and HPLC analyses. |
| Source: | Escherichia coli. |
| Biological Activity: | Test in Process. |
| Formulation: | 0.2μmfiltered concentrated solution in 25mMTris-HCl,pH 8.0,100mM NaCl,1 mM DTT,30% Glycerol,with Tween-80. |
| 内毒素 | Less than 0.1 EU/μg of rHuBcl-2 as determined by LAL method. |
| 氨基酸序列 | AHAGRTGYDN REIVMKYIHY KLSQRGYEWD AGDVGAAPPG AAPAPGIFSS QPGHTPHPAA SRDPVARTSP LQTPAAPGAA AGPALSPVPP VVHLTLRQAG DDFSRRYRRD FAEMSSQLHL TPFTARGRFA TVVEELFRDG VNWGRIVAFF EFGGVMCVES VNREMSPLVD NIALWMTEYL NRHLHTWIQD NGGWDAFVEL YGPSMRPLFD |
相关搜索：重组人Bcl-2，Bcl-2, Human，Recombinant Human B-cell Lymphoma 2